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A current view of G protein-coupled receptor - mediated signaling in pulmonary hypertension: finding opportunities for

Liver-on-a-Chip Sinusoidal Constructs These LoC models involve coculturing different cell types with HCs, such as LSECs, and macrophages, as well as incorporating shear flow to enhance liver functions, such as urea secretion and protein synthesis

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Conversely, downregulation of CHAC1/BOTCH was associated with increased neuronal damage and impaired recovery ( The regulation of CHAC1/BOTCH involves additional molecular players: during intracerebral hemorrhage, inhibition of CHAC1/BOTCH by the androgen receptor (AR) and Jumonji-domain containing protein-3 (JMJD3) led to elevated NOTCH1 levels and exacerbated neuroinflammation ( ATF4 was most prominently upregulated, though other related genes were also significantly elevated (Yasuda et al., 2014)