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Oxidative stress and GPX2 control pancreatic vs. non-pancreatic cell fate in human endoderm | Nature Communications

The expression of fatty acid synthase (FASN), a key enzyme essential for the FAS, is elevated in breast cancer ( FASN gene is upregulated due to the arousal of AKT and SREBP-1 in breast tumor cells ( Overview of Metastasis in Breast Cancer Tumor metastasis is a sequential multi-step process, which includes local invasion, intravasation, migration through the lymphatics or blood vessels, extravasation and colonization giving rise to the formation of metastases in distant organs ( The Process of Metastasis The step one of the metastasis is that tumor cells break away from the tumor bed and migrate from the stroma into the bloodstream ( After escaping from the original tumor site to blood circulation, breast tumor cells begin to migrate to remote organs

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While receptor depletion from the plasma membrane occurs due to the β -arresitin binding-induced endocytosis [26], it is reasonable to assume that the receptors are still synthesized and replenished with a rate r s , which leads to the following evolution equation for the receptor density on the cell surface: Dephosphorylation and resensitization of receptor In the longer time scale, it was suggested that typically only after the receptor internalization, protein phosphotases (PPs) are at work in an acidic endosomal compartment to dephosphorylate, resensitize and restore the receptor back to the cell surface [48, 50, 56, 57]